Mayo Clinic and Microsoft have formed a collaboration to develop and deploy an AI model for healthcare.
Mayo Clinic will own the model.
The agreement combines Mayo Clinic's clinical expertise and de-identified patient data with Microsoft's AI and cloud engineering to build what the organisations describe as a frontier model for medical use.
According to the organisations, the system is designed to handle a wide range of clinical reasoning tasks and healthcare applications. It is intended to draw on different forms of clinical data to support diagnosis, treatment decisions, and care management.
The model will first be deployed in Mayo Clinic's own clinical environment, where it can be tested and refined through real-world use. The approach reflects the stricter governance demands in healthcare, where AI systems must account for clinical context, longitudinal records, and validation in practice.
Clinical deployment
Microsoft plans to offer access to the model through Azure Foundry APIs, allowing healthcare organisations and other users to adopt the system more broadly once it becomes available.
The collaboration gives Mayo Clinic ownership of the model, a structure the healthcare group said reflects its focus on patient trust, clinical standards, and stewardship of data used in AI development.
Mayo Clinic has spent several years building its data and digital health capabilities through Mayo Clinic Platform, which it launched to create a de-identified data foundation for research and product development.
Healthcare focus
Healthcare providers and technology companies have stepped up efforts to build AI tools tailored to medical settings rather than relying on general-purpose models. Such systems require access to large volumes of clinical information and must operate under tighter safety and privacy expectations than consumer applications.
The partners said the goal is to make Mayo Clinic's model of care and medical knowledge more widely available. They said the work could help clinicians manage difficult decisions and give patients more timely insight.
Long-term strategy
Gianrico Farrugia described the project as part of a longer-term effort to use AI in medicine.
"Mayo Clinic is committed to putting patients first, and we have long believed AI can help transform healthcare. Seven years ago, we launched Mayo Clinic Platform to move healthcare from a pipeline to a platform model through a safe, trusted, patient-centric de-identified data foundation designed to accelerate innovation, breakthroughs, and cures," said Gianrico Farrugia, President and Chief Executive Officer, Mayo Clinic.
"Now, by combining our clinical expertise and data foundation with Microsoft's engineering and AI capabilities, we are building something healthcare has never seen before and bringing more of Mayo Clinic to more patients," said Farrugia.
Microsoft framed the effort as a step toward more advanced medical AI trained on healthcare-specific information and informed by clinicians.
"Frontier medical intelligence is around the corner. This is the best collaboration imaginable to help us accelerate toward that future. Mayo has unparalleled clinical expertise, de-identified clinical health data, and longitudinal medical insights, and we're thrilled to partner with their world-class physicians to build a state-of-the-art foundation model for healthcare," said Mustafa Suleyman, Chief Executive Officer, Microsoft AI.